COUGH in DUCHENNE and BECKER - Peak Cough Flow and Cough Clearance in Duchenne and Becker Muscular Dystrophy


Frequently Asked Questions (FAQs) about this study:


What stage is this research?

  • This study is actively recruiting boys and young men with Duchenne or Becker muscular dystrophy.


What is the goal or purpose of this study?

  • The goal is to determine whether physiologic measures (peak cough flow, measures of respiratory muscle strength including MIP, MEP, SNIP, and spirometry) can predict the ability to clear the airways of secretions with cough (spontaneous cough clearance, as measured by a nuclear medicine study) in children with neuromuscular disease. It will also determine whether airway clearance is augmented by high frequency chest wall oscillation.


Who is sponsoring this study?

  • This study is sponsored by the University of Pittsburgh and Respirtech, Inc.


Who is eligible to participate in this study?

  • Researchers are recruiting boys and young men with Duchenne or Becker who are between the ages of 6 years to 21 years old. Participants must not need mechanical ventilation during the day. 


What do I have to do if I decide to participate in this study?

  •  If you and your child decide to take part in this study, your child would be asked to first perform several pulmonary function tests (spirometry and measurement of respiratory muscle strength and peak cough flow). Next, subjects would inhale a radioactive “tracer” that can be seen on a special imaging camera. Your child would then be asked to cough several times over the next several minutes. Following this, they would wear a special oscillating chest vest for 30 minutes, during which they would be asked to periodically cough. The study typically lasts about 3 hours in total.


Where does this study take place?

  • This study is taking place at the Children’s Hospital of Pittsburgh in Pittsburgh, PA


Will I get paid for participating in this study?

  • Yes, families will be compensated to thank them for their time.  Families will also be reimbursed for mileage costs.


Why should I consider participating in this study?

  • While no personal benefit can ever be guaranteed by participation in a study, there are other benefits, including allowing you to play an active role in your own health care (or that of your child), gaining access to medical specialists that are normally not available to you or your child, and helping others by contributing to the better understanding of Duchenne.


Where can I learn more about this study?

  • For more information, please contact Paul Rebovich, MS at 412-692-5873, or This email address is being protected from spambots. You need JavaScript enabled to view it..
  • You can learn more about this study at (NCT02034305).
  • Please check for updates to this FAQ sheet.